Recent progress in the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases
Small RNA (known as microRNA,miRNA) is single-stranded non-coding RNA (18-25 nucleotides length),it regulates various proteins by targeting the 3'-untranslated region (3-UTR) of various transcripts,thus dysregulation of miRNA affects a wide range of processes such as cell proliferation and differentiation involved in organ remodeling processes.Current studies demonstrated that post-transcriptional effect of miRNA is involved in the development of chronic liver diseases,while hepatic stellate cells (HSCs) play a vital role in the primary formation of ECM and undergo progressive activation to become myofibroblasts (MFB)-like cells.The aim of this paper is to discuss the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases.
国家科技期刊平台
NSTL
万方数据
维普
