高原低氧诱导肠稳态失衡的分子机制及中药防治研究进展
Molecular mechanism of high altitude hypoxia induced intestinal ho-meostasis imbalance and research progress of traditional Chinese medicine
康倩 1修明慧 2张雪燕 3杨丹 1王树威 3和建政 4龚红霞 4曹旺杰 4苏韫4
作者信息
- 1. 甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,兰州 730000,甘肃;甘肃中医药大学,基础医学院,兰州 730000,甘肃
- 2. 甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,兰州 730000,甘肃;甘肃中医药大学,敦煌医学与转化教育部重点实验室,兰州 730000,甘肃;甘肃中医药大学,公共卫生学院,兰州 730000,甘肃
- 3. 甘肃中医药大学,公共卫生学院,兰州 730000,甘肃
- 4. 甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,兰州 730000,甘肃;甘肃中医药大学,敦煌医学与转化教育部重点实验室,兰州 730000,甘肃;甘肃中医药大学,基础医学院,兰州 730000,甘肃
- 折叠
摘要
低氧是限制人群在高原生存的因素之一,能够引起呕吐腹泻、心慌气短、急性昏迷等症状.患有急性高原病的人约80％至少有一种胃肠道不适的症状,如厌食、恶心、腹泻、呕吐等.研究高原低氧所致肠损伤的病理特点、发病机制及药物防治,有利于高原胃肠道疾病的诊治.因此,本文通过总结相关文献,就高原低氧造成肠道损伤的相关研究进行系统阐述,对高原低氧造成肠道形态学、肠道细胞、肠道菌群等肠稳态的改变,引起肠道炎症、氧化损伤等机制及中药防治进行总结,以期为科研工作者和临床工作者提供借鉴及信息参考.
Abstract
Hypoxia is one of the factors restrict-ing the survival of people at high altitudes,which can cause various symptoms such as vomiting,diar-rhea,palpitations,shortness of breath and acute coma.About 80％of patients with acute mountain sickness have at least one symptom of a gastroin-testinal distress(e.g.,anorexia,nausea,diarrhea,vomiting,etc.).The pathological characteristics,pathogenesis and drug treatment of intestinal inju-ry caused by high-altitude hypoxia were studied,which is conducive to the diagnosis and treatment of plateau gastrointestinal diseases.Therefore,by summarized relevant literature and systematically expounds the related researches on intestinal dam-age caused by high altitude hypoxia.We summa-rized the changes of intestinal morphology,intesti-nal cells,intestinal flora and other intestinal ho-meostasis caused by high altitude hypoxia,the mechanism of intestinal inflammation and oxida-tive damage,and the treatment of traditional Chi-nese medicine,which provide reference and infor-mation for reference for scientific research workers and clinicians.
关键词
高原低氧/肠稳态失衡/抗缺氧/炎症/氧化损伤Key words
high-altitude hypoxia/intestinal ho-meostasis imbalance/anti-hypoxia/inflammation/oxidative damage引用本文复制引用
基金项目
国家自然科学基金(82004228)
甘肃省自然科学基金(21JR11RA144)
202甘肃省高等学校青年博士基金(2022QB-102)
甘肃省中医药管理局项目(GZKP-2021-32)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据