钠钙交换体与射血分数保留型心力衰竭研究进展
Research progress in sodium calcium exchanger and heart failure with preserved ejection fraction
陈峰 1黄鈺婷 2王笑 1樊官伟1
作者信息
- 1. 天津中医药大学第一附属医院,天津市中医方证转化研究重点实验室,天津 300193;天津中医药大学,国家中医针灸临床医学研究中心,天津 301617
- 2. 赣南医学院第一附属医院,心脑血管疾病防治教育部重点实验室,赣州 341099,江西
- 折叠
摘要
钠钙 交换体(sodium-calcium exchanger,NCX)由SCL8家族基因编码且属于阳离子反向转运蛋白家族一员,是一种广泛分布在膜结构上的阳离子转运蛋白,控制细胞钙的外流和内流,对维持细胞内钙浓度稳态及正常心功能起着关键作用;射血分数保留型心力衰竭(heart failure with preserved ejection fraction,HFpEF)具有高发病率、高住院率和高死亡率的特点,且目前没有理想的治疗方法.在HFpEF中,NCX反向模式过表达,心脏的舒张功能受损,心肌细胞钙瞬变因HFpEF的病因不同而存在差异.目前,以NCX为靶点的多种特异性抑制剂,能特异性抑制钙内流改善HFpEF的舒张功能障碍,提高HFpEF模型存活率,积极开发靶向抑制NCX的化合物是一个重要的科学挑战.
Abstract
Sodium calcium exchanger(NCX)is en-coded by the SCL8 family genes and belongs to the cation/Ca2+exchanger superfamily.It is a widely dis-tributed cation transporter protein on membrane structures,controlling the outflow and inflow of cellular calcium,and playing a key role in maintain-ing stable intracellular calcium concentration and normal cardiac function;Heart failure with pre-served ejection fraction is characterized by high morbidity,high hospitalization rate and high mor-tality,and there is no ideal treatment method at present.In HFpEF,overexpression of NCX reverse mode leads to impaired diastolic function of the heart,and calcium transient in myocardial cells var-ies depending on the etiology of HFpEF.At present,various specific inhibitors targeting NCX can specifi-cally inhibit calcium influx,improve diastolic dys-function of HFpEF,and improve the survival rate of HFpEF models.Actively developing compounds tar-geting NCX inhibition is an important scientific chal-lenge.
关键词
钠钙交换体/射血分数保留型心力衰竭/钠钙交换体抑制剂Key words
sodium calcium exchanger/heart fail-ure with preserved ejection fraction/sodium calci-um exchanger inhibitors引用本文复制引用
基金项目
天津市教委科研计划重点项目(2021ZD012)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据