褪黑素在缺血再灌注损伤治疗中作用的研究进展
Research progress on the role of melatonin in the treatment of isch-emia-reperfusion injury
金学磊 1录亚鹏 1邸雪睿 1郑奇辉 1石翊飒1
作者信息
- 1. 兰州大学第二医院麻醉科,兰州 730000,甘肃
- 折叠
摘要
缺血再灌注(ischemia-reperfusion,I/R)作为一种复杂血流动力学过程,可通过氧化应激、线粒体功能障碍和炎症反应等引起组织损伤,是导致患者预后不良的重要因素,探究其有效防治措施具有重要临床意义.褪黑素作为一种具有强大抗氧化及抗炎特性的内源性激素,在降低细胞死亡、改善组织I/R损伤方面具有重要作用.因此,本文就褪黑素与器官I/R损伤的关系进行综述,以期为褪黑素应用于临床减轻器官I/R损伤提供理论依据.
Abstract
Ischemia-reperfusion(I/R)is a com-plex hemodynamic process that can cause tissue damage through oxidative stress,mitochondrial dysfunction,and inflammatory reactions.It is an important factor leading to poor prognosis in pa-tients,and the exploration of effective prevention and treatment measures is of significant clinical sig-nificance.As an endogenous hormone with strong antioxidant and anti-inflammatory properties,Mel-atonin plays an important role in reducing cell death and improving tissue I/R injury.Therefore,this article reviews the relationship between Mela-tonin and organ I/R injury in order to provide a the-oretical basis for the clinical application of melato-nin to alleviate organ I/R injury.
关键词
褪黑素/缺血再灌注损伤/器官保护Key words
melatonin/ischemia reperfusion inju-ry/organ protection引用本文复制引用
基金项目
甘肃省自然科学基金(22JR5RA980)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据