JAK/STAT信号通路干预糖尿病微血管并发症研究进展
Research progress of JAK/STAT signaling pathway in the intervention of diabetic microvascular complications
李涛 1杨丽霞 2高博 3李钦 3宋爽3
作者信息
- 1. 甘肃中医药大学中医临床学院,兰州 730000,甘肃
- 2. 甘肃省中医药研究院,兰州 730050,甘肃
- 3. 甘肃卫生职业学院,兰州 730000,甘肃
- 折叠
摘要
糖尿病微血管并发症是导致糖尿病患者高病死率的主要原因,现有治疗药物仍有很大不足,亟需更为有效的新药.Janus激酶/信号转导与转录激活子(JAK/STAT)参与糖尿病微血管并发症的进展,通过调控该途径可以改善糖尿病微血管并发症.因此,本文综述JAK/STAT参与糖尿病微血管并发症(糖尿病肾脏病、糖尿病视网膜病变、糖尿病周围神经病变)的进展,并从治疗药物、临床前药物、中药三方面,将近年来干预JAK/STAT改善糖尿病微血管并发症的潜在药物进行综述,以期能为糖尿病微血管并发症的药物研发及治疗提供思路.
Abstract
Diabetic microvascular complications are the main reason for the high mortality of dia-betic patients.There is still a great shortage of ex-isting therapeutic drugs,so there is an urgent need for more effective new drugs.Janus kinase/signal transducer and activator of transcription(JAK/STAT)is involved in the progression of diabetic microvas-cular complications,which can be improved by reg-ulating this pathway.Therefore,this article reviews the progress of JAK/STAT in diabetic microvascular complications(diabetic kidney disease,diabetic ret-inopathy,diabetic peripheral neuropathy),and summarizes the potential drugs that intervene JAK/stat to improve diabetic microvascular complica-tions in recent years from three aspects of thera-peutic drugs,preclinical drugs,and traditional Chi-nese medicine,in order to provide ideas for drug development and treatment of diabetic microvas-cular complications.
关键词
糖尿病微血管并发症/JAK/STAT/中药Key words
diabetic microvascular complica-tions/JAk/STAT/traditional Chinese medicine引用本文复制引用
基金项目
甘肃省中医药管理局项目(GZKP-2021-39)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据