目的:观察苏贝止咳颗粒(Su Bei Zhi Ke granules，SBZKG)对急性气管-支气管炎(风寒袭证)的影响。方法:采用小鼠耳廓肿胀实验、小鼠腹腔毛细血管通透性实验，观察其抗炎作用;小鼠排泌酚红实验、氨水所致小鼠咳嗽实验和大鼠排痰实验，观察其祛痰、止咳作用;采用感染小鼠死亡率实验，观察其抗菌、抗病毒作用。结果:与对照组比较，SBZKG大、中剂量组均降低小鼠耳廓肿胀度(P＜0。05)和提高肿胀抑制率，降低小鼠腹腔毛细血管通透性(P＜0。05，P＜0。01);SBZKG可增加小鼠呼吸道的酚红排痰量(P＜0。01)，延长小鼠咳嗽潜伏期，减少小鼠咳嗽次数(P＜0。05，P＜0。01)和增加大鼠的排痰量(P＜0。05，P＜0。01);SBZKG可减少小鼠感染细菌和病毒后的死亡率。结论:SBZKG具有一定的抗炎、止咳、祛痰、抗菌、抗病毒作用，对急性气管-支气管炎具有一定的治疗作用。
Experimental study on pharmacodynamics of Su Bei Zhi Ke granules(SBZKG)for acute tracheobronchitis
AIM:To observe the effect of Su Bei Zhi Ke granules(SBZKG)on acute tracheobronchitis(Syndrome of Wind-cold Attacking Lung).METH-ODS:Mouse ear swelling experiment and mouse abdominal capillary permeability experiment was used to observe its anti-inflammatory effect.Cough test in mice induced by ammonia water,and phlegm test in rats were used to observe the expec-torant and antitussive effects of phenol red test in mice.We used the mortality rate experiment of in-fected mice to observe its antibacterial and antivi-ral effects.RESULTS:Compared with the contral group,the large and medium dose groups of SBZKG both reduced mouse auricle swelling(P＜0.05)and increased swelling inhibition rate,reducing mouse abdominal capillary permeability(P＜0.05,P＜0.01).SBZKG can increase the phenol red sputum output in the respiratory tract of mice(P＜0.01),prolong the cough incubation period of mice,reduce the number of coughs in mice(P＜0.05,P＜0.01),and in-crease the sputum output in rats(P＜0.05,P＜0.01).SBZKG can reduce the mortality rate of mice infect-ed with bacteria and viruses.CONCLUSION:SBZKG has certain anti-inflammatory,antitussive,expecto-rant,antibacterial and antiviral effects,and has cer-tain therapeutic effects on acute tracheobronchitis.
Su Bei Zhi Ke granulesacute tracheo-bronchitisstop coughexpectorantantibacterialantiviral
国家科技期刊平台
NSTL
万方数据
维普
