苏贝止咳颗粒急性气管支气管炎药效学实验研究
Experimental study on pharmacodynamics of Su Bei Zhi Ke granules(SBZKG)for acute tracheobronchitis
阚红卫 1田军2
作者信息
- 1. 国家药品监督管理局药品审评检查长三角分中心,上海 201210
- 2. 安徽省食品药品检验研究院,合肥 230051,安徽
- 折叠
摘要
目的:观察苏贝止咳颗粒(Su Bei Zhi Ke granules,SBZKG)对急性气管-支气管炎(风寒袭证)的影响.方法:采用小鼠耳廓肿胀实验、小鼠腹腔毛细血管通透性实验,观察其抗炎作用;小鼠排泌酚红实验、氨水所致小鼠咳嗽实验和大鼠排痰实验,观察其祛痰、止咳作用;采用感染小鼠死亡率实验,观察其抗菌、抗病毒作用.结果:与对照组比较,SBZKG大、中剂量组均降低小鼠耳廓肿胀度(P＜0.05)和提高肿胀抑制率,降低小鼠腹腔毛细血管通透性(P＜0.05,P＜0.01);SBZKG可增加小鼠呼吸道的酚红排痰量(P＜0.01),延长小鼠咳嗽潜伏期,减少小鼠咳嗽次数(P＜0.05,P＜0.01)和增加大鼠的排痰量(P＜0.05,P＜0.01);SBZKG可减少小鼠感染细菌和病毒后的死亡率.结论:SBZKG具有一定的抗炎、止咳、祛痰、抗菌、抗病毒作用,对急性气管-支气管炎具有一定的治疗作用.
Abstract
AIM:To observe the effect of Su Bei Zhi Ke granules(SBZKG)on acute tracheobronchitis(Syndrome of Wind-cold Attacking Lung).METH-ODS:Mouse ear swelling experiment and mouse abdominal capillary permeability experiment was used to observe its anti-inflammatory effect.Cough test in mice induced by ammonia water,and phlegm test in rats were used to observe the expec-torant and antitussive effects of phenol red test in mice.We used the mortality rate experiment of in-fected mice to observe its antibacterial and antivi-ral effects.RESULTS:Compared with the contral group,the large and medium dose groups of SBZKG both reduced mouse auricle swelling(P＜0.05)and increased swelling inhibition rate,reducing mouse abdominal capillary permeability(P＜0.05,P＜0.01).SBZKG can increase the phenol red sputum output in the respiratory tract of mice(P＜0.01),prolong the cough incubation period of mice,reduce the number of coughs in mice(P＜0.05,P＜0.01),and in-crease the sputum output in rats(P＜0.05,P＜0.01).SBZKG can reduce the mortality rate of mice infect-ed with bacteria and viruses.CONCLUSION:SBZKG has certain anti-inflammatory,antitussive,expecto-rant,antibacterial and antiviral effects,and has cer-tain therapeutic effects on acute tracheobronchitis.
关键词
苏贝止咳颗粒/急性气管-支气管炎/止咳/祛痰/抗菌/抗病毒Key words
Su Bei Zhi Ke granules/acute tracheo-bronchitis/stop cough/expectorant/antibacterial/antiviral引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据