Research progress on drug treatment and drug resistance mechanism of gastrointestinal stromal tumors
Gastrointestinal stromal tumors(GIST)are the most common mesenchymal-derived tu-mors of the gastrointestinal tract.Tyrosine kinase inhibitors(TKIs)are the cornerstone of GIST thera-py,but mutations in resistance genes pose many problems for treatment,especially the heterogene-ity of KIT resistance mutations.In recent years,with the release of a number of GIST related drug research and experimental results,the great poten-tial of targeted therapy,immunotherapy and com-bination therapy to treat GIST in different direc-tions has been revealed,providing more therapeu-tic directions for GIST.This article will review the experimental research and future direction in re-cent years.
stromal tumors of the gastrointesti-nal tractdrug therapydrug resistance mecha-nismsresearch progress
国家科技期刊平台
NSTL
万方数据
维普
