间充质干细胞对OSAHS病理生理调节机制的研究进展
Advances in the study of mesenchymal stem cells in obstructive sleep apnea hypoventilation syndrome
许金回 1岳红梅 2李雅亭 1刘苗苗 1武兴东 1朱浩斌1
作者信息
- 1. 兰州大学第一临床医学院,兰州 730000,甘肃
- 2. 兰州大学第一临床医学院,兰州 730000,甘肃;兰州大学第一医院呼吸与危重症医学科,兰州 730000,甘肃
- 折叠
摘要
间充质干细胞(MSCs)是一种自我再生、快速增殖的多能干细胞,主要依赖其衍生的促血管生成、炎症调节和营养因子发挥有益作用.这些因子能减弱有害的炎症反应,减少血管损伤,促进组织修复和再生.阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种慢性疾病,其标志是睡眠过程中口咽塌陷,导致短暂的气流减少,胸内压力大幅波动,以及间歇性缺氧和高碳酸血症.OSAHS存在细胞因子介导的炎症级联反应、氧化应激和缺血,从炎症和损伤组织中招募MSCs,通过MSCs衍生的抗炎和促进血管生成因子的活性,在OSAHS损伤组织中降低缺氧、抑制炎症、促进再生、防治纤维化.本文将从OSAHS角度阐述炎症、氧化应激、纤维化和缺血的发病机制,着重介绍目前关于MSCs依赖调节OSAHS相关病理的研究进展.
Abstract
Mesenchymal stem cells(MSCs)are self-regenerating,rapidly proliferating pluripotent stem cells that depend primarily on their derived pro-angiogenic,inflammatory regulatory,and tro-phic factors to exert beneficial effects that attenu-ate deleterious inflammatory responses,reduce vascular damage,and promote tissue repair and re-generation.Obstructive sleep apnea hypoventila-tion syndrome(OSAHS)is a chronic disorder marked by oropharyngeal collapse during sleep,re-sulting in transient reduced airflow,large fluctua-tions in intrathoracic pressure,and intermittent hy-poxia and hypercapnia.OSAHS subsequently cyto-kine-mediated inflammatory cascades,oxidative stress,and ischemia,recruit MSCs from inflamed and damaged tissues through MSCs-derived of anti-inflammatory and pro-angiogenic factor activity,re-duce hypoxia,suppress inflammation,promote re-generation,and prevent fibrosis in OSAHS-injured tissues.In this paper,we will describe the patho-genesis of inflammation,oxidative stress,fibrosis and ischemia from the perspective of OSAHS,high-lighting the current research progress on MSCs-de-pendent regulation of OSAHS-related pathology.
关键词
阻塞性睡眠呼吸暂停低通气综合征/间充质干细胞/作用机制/研究进展Key words
obstructive sleep apnea hypoventila-tion syndrome/mesenchymal stem cells/mecha-nism of action/research progress引用本文复制引用
基金项目
甘肃省科技计划(科技重大专项计划)(22ZD1FA001)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据