Emerging evidences suggest that fer-roptosis plays a vital role in the pathophysiological process of brain injury after Ischemic stroke.Accu-mulating evidence supports pharmacological inhi-bition of ferroptosis as a therapeutic target for brain injury after Ischemic stroke through activat-ing nuclear factor erythroid 2-related factor 2(Nrf2),which transcriptionally controls many key components of the ferroptosis pathway.In this re-view,briefly describe ferroptosis processes and the roles they play in contributing to brain injury after ischemic stroke in the brain.We then provide a crit-ical overview of the relationship between Nrf2 sig-nalling and ferroptosis.With a focus on discuss how therapeutic modulation of the Nrf2 pathway is a viable strategy to explore in the treatment of fer-roptosis-driven brain injury after Ischemic stroke.
关键词
铁死亡/Nrf2/缺血性脑卒中/缺血性脑卒中后脑损伤
Key words
ferroptosis/Nrf2/ischemic stroke/brain injury after ischemic stroke
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