Perioperative bleeding is closely relat-ed to the prognosis of patients,and massive blood loss can lead to serious adverse events.Tranexamic acid,a lysine derivative,exerts anti-fibrinolytic ef-fects by competitively blocking lysine binding sites on plasminogen to achieve hemostasis.Periopera-tive use of tranexamic acid can effectively reduce the risk of bleeding and the need for blood transfu-sion,and reduce the risk of bleeding related com-plications and death.At present,the use of tranexamic acid for perioperative hemostasis is in-creasingly widespread,and it is gradually entering the consensus and guidelines in more surgical fields.In this paper,the mechanism of action,peri-operative application and adverse reactions of tranexamic acid were reviewed,and the effective-ness and safety of tranexamic acid in different sur-gical types were discussed,so as to provide refer-ence for the application and research of tranexamic acid in China.
维普
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