Endometrial cancer originates from the endometrium and is one of the common gyne-cologic malignancies,with its incidence and mortal-ity rate increasing year by year.Although endome-trial cancer is more prevalent in the peri-and post-menopausal female population,it has been an evi-dent trend in recent years towards younger pa-tients.For young patients who have not yet given birth but intend to do so,the application of proges-tins in endometrial cancer treatment has made sig-nificant progress in clinical practice.Considering the existence of large individual differences and un-clear mechanisms of action in the clinical applica-tion of progestins,this paper aims to provide an overview of the current clinical application status,efficacy,hormone resistance,and its mechanisms in the context of hormone therapy.
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