Feasibility of remimazolam mimic propofol Marsh mode target-con-trolled infusion during anesthesia
AIM:To evaluate the feasibility of Marsh target-controlled infusion of simulated pro-pofol with remimazolam for induction and mainte-nance of anesthesia in patients undergoing laparo-scopic gallbladder surgery.METHODS:A total of 80 patients undergoing elective laparoscopic gallblad-der surgery were randomly divided into propofol group(Group P)and remimazolam group(Group R),with 40 cases in each group.Anesthesia was in-duced and maintained by target-controlled infusion of propofol and remimazolam respectively(Marsh mode,plasma target concentration).The time of loss of consciousness was recorded,and HR,MAP and BIS were induced before intubation(T0),imme-diately after intubation(T1),3min after intubation(T2),immediately after pneumoperitoneum(T3),30min during surgery(T4),and after surgery(T5).Injection pain,tracheal extubation time and post-operative adverse reactions were recorded.RE-SULTS:Compared with Group P,the loss of con-sciousness in Group R was shorter(P＜0.05),the in-cidence of injection pain,intraoperative hypoten-sion and bradycardia was lower(P＜0.05),but the postoperative extubation time was longer(P＜0.05).CONCLUSION:Remimazolam can be applied to the Marsh mode of propofol,and Remimazolam mimic target-controlled infusion(Marsh mode)has a good effect and safety on inducing and maintaining sedation under general anesthesia,as well as the vi-tal signs are stable.
remimazolampropofoltarget-con-trolled infusion(Marsh mode)anesthesiainduc-tion and maintenance
国家科技期刊平台
NSTL
万方数据
