Pharmacological characteristics of esketamine and its application progress in pediatric anesthesia
Esketamine is an antagonist of the N-methyl-D-aspartate(NMDA)receptor and exerts an-tianxiety,hypnotic,sedative,and analgesic effects by interacting with NMDA receptors,opioid recep-tors,M-choline receptors,monoamine receptors,adenosine receptors,and other purine receptors.As the more potents isomer of ketamine,it is about twice as potent as ketamine.Compared with ketamine,esketamine has the characteristics of rap-id onset and metabolism,strong analgesia,slight respiratory depression,rapid recovery of cognitive function,and low incidence of psychiatric side ef-fects.It has become a new choice of pediatric anes-thesia drugs.This article reviews the pharmacologi-cal properties of esketamine and its recent applica-tion in pediatric anesthesia,and provides reference for the safe use of esketamine in pediatric perioper-ative period.
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