COVID-19,a disease caused by SARS-CoV-2 infection,has caused a global pandemic in a short time.The key immunopathological features of COVID-19 include lymphopenia,neutropenia,cy-tokine storm and related Immune damage to pa-renchymal organs such as lung.Granulocyte colony stimulating factor(G-CSF)can cause excessive in-flammatory reaction,which may aggravate the con-dition of some patients.Therefore,it is controver-sial whether COVID-19 should be treated with G-CSF,and clinicians need to evaluate the effective-ness and safety of G-CSF according to the specific conditions of each patient.