The attenuating and potentiating effects of traditional Chinese medi-cine in immune checkpoint therapy
Immunotherapy has become a global focus in cancer clinical practice and scientific re-search.In the past two years,PD-1\PD-L1 and CTLA-4 inhibitors,especially Nivolumab,Pembrolizumab,Atezolizumab and Lpilimumab,have been used in non-small cell lung cancer,colon cancer.Promising results have been obtained in malignancies such as melanoma and urinary tract cancer.Traditional Chi-nese medicine has a long history in China.Modulat-ing immune checkpoints has certain advantages in treating malignant tumors,and it has shown good efficacy in improving its adverse events.This article reviews the role of traditional Chinese medicine in regulating immune checkpoints and improving ad-verse reactions and its application prospects in im-munomodulatory treatment.
traditional Chinese medicinemalig-nant tumoursimmune checkpointimmunothera-pyadverse reaction