Progress in researches for perampanel in the treatment of comorbidi-ties of epilepsy
Sleep disorder,migraine,cognitive and behavioral disorders,anxiety and depression are common comorbidities of epilepsy.The comor-bidity rate of epilepsy patients is eight times that of the general population,which affects the prognosis and quality of life of epilepsy patients.Perampanel(PER),as a third-generation antiseizure medication,has shown promising clinical research and applica-tion in the treatment of comorbidities in epilepsy.PER can improve the total sleep time,sleep latency and sleep efficiency of patients with epilepsy co-morbid sleep disorder.PER also shows good effica-cy in reducing seizure and migraine attacks of pa-tients with epilepsy comorbid migraine.Mean-while,the impact of PER on overall cognitive char-acteristics is neutral,with no systematic cognitive deterioration or improvement,but behavioral changes are one of the most common adverse events related to PER.For patients with comorbid anxiety and depression,PER does not exacerbate the anxiety and depression of epilepsy patients,and the severity of anxiety and depression in some patients will improve.This article will review the mechanism of action and clinical treatment re-search progress of PER on comorbidities of epilepsy.
perampanelcomorbidities of epilep-sysleep disordermigrainecognition
国家科技期刊平台
NSTL
万方数据
