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过敏原特异性免疫治疗在过敏性气道疾病中的应用进展

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过敏原特异性免疫治疗(allergen immu-notherapy,AIT)是明确患者过敏原后,给患者反复接触过敏原提取物,并逐渐增加浓度和剂量直到达到目标维持剂量,从而使患者对过敏原产生耐受,这是至今惟一一种可以调控变应性疾病发病机制进而改变其自然进程的治疗方法.近年来国内外学者在AIT临床实践和研究领域均取得较大进展,本文对AIT的作用机制、疗效和给药途径等研究进展进行概述.
Progress in the application of AIT in allergic airway diseases
Allergen specific immunotherapy(AIT)is to identify the patient's allergen,give the patient repeated exposure to the allergen extract,and gradually increase the concentration and dose until the target maintenance dose is reached,so that the patient can develop tolerance to the allergen,which is the only treatment that can regulate the pathogenesis of allergic diseases and change its natural course.In recent years,domestic and for-eign scholars have made great progress in the clini-cal practice and research field of AIT.This article re-viewed the relevant progress of the mechanism,ef-ficacy and drug administration of AIT.

allergen immunotherapyallergic asthmaallergic rhinitis

王林林、马圆、陈智鸿、计海婴

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复旦大学附属中山医院呼吸与危重症医学科,上海 200032

过敏原特异性免疫治疗 过敏性哮喘 过敏性鼻炎

国家自然科学基金国家自然科学基金

8200008782270026

2024

中国临床药理学与治疗学
中国药理学会

中国临床药理学与治疗学

CSTPCD北大核心
影响因子:0.97
ISSN:1009-2501
年,卷(期):2024.29(4)
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