摘要
目的:本研究旨在探究去银合剂治疗银屑病的疗效,并分析其疗效与不同影响因素之间的关系及其对生物制剂治疗的增效作用.方法:本研究纳入共396例银屑病患者,根据病史将患者分为生物制剂组(n=98)、去银合剂辅助生物制剂组(n=62)、去银合剂单用组(n=236).收集病史资料中患者的性别、病程、疾病类型、初始发病部位、瘙痒程度、复发与否及复发时间、是否长期吸烟、关节疼痛情况、银屑病家族史、指、趾甲损害、治疗方案及银屑病面积严重程度指数(PASI)、体表面积评分(BSA).分析去银合剂疗效的影响因素并分析其与生物制剂联用的效果.结果:去银合剂辅助生物制剂治疗后,患者PASI90应答率升高至72.6％(P=0.014).去银合剂治疗应答PASI50的患者中,复发间隔超过半年较未应答者增多(50％vs.33.6％,P=0.045).银屑病皮损体表面积(OR=0.960,P=0.000)、长期吸烟史(OR=2.10,P=0.046)及银屑病类型(OR=2.47,P=0.015)皆为去银合剂疗效的影响因素.结论:去银合剂对生物制剂治疗银屑病有增效作用,并在复发间隔大于半年的患者中更具优势.长期吸烟史、银屑病类型及皮损体表面积皆可影响去银合剂的疗效.
Abstract
AIM:To assess the efficacy of Quyin Koufuye in different types of psoriasis vulgaris and analyzes the relationship between efficacy and vari-ous disease-related factors,as well as its comple-mentary role in biologic therapy.METHODS:This study included a total of 396 patients with psoria-sis.Based on the patient history,participants were categorized into the biologics group(n=98),Quyin Koufuye-assisted biologics group(n=62),and Quyin Koufuye monotherapy group(n=236).Patient histo-ry data were collected,including gender,duration of illness,disease type,initial site of onset,degree of itching,recurrence status and time,smoking habits,joint pain,family history of psoriasis,nail damage,treatment plan,and PASI/BSA scores.A retrospective analysis was conducted to identify factors influencing the efficacy of Quyin Koufuye and to analyze its combined effects with biologics.RESULTS:Combining Quyin Koufuye with biologics significantly boosted the PASI90 response rate to 72.6％(P=0.014).Responders to PASI50 with Quyin Koufuye experienced longer recurrence intervals(＞6 months)than non-responders(50％vs.33.6％,A=0.045).Influencing factors included psoriasis-affect-ed body surface area(OR=0.960,P=0.000),pro-longed smoking history(OR=2.10,P=0.046),and psoriasis type(OR=2.47,P=0.015).CONCLUSION:This study underscores the synergy of Quyin Kou-fuye and biologics in treating psoriasis,particularly for longer recurrence intervals-factors like smoking history,psoriasis type,and affected body surface area impact Quyin Koufuye's efficacy.
维普
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