核受体调控糖尿病肾病脂质积累及中药复方干预的研究进展
Progress in the treatment of lipid deposition in diabetic nephropathy with traditional Chinese medicine targeting nuclear receptors
朱文辉 1陈瑶 1张永刚 2刘鹏3
作者信息
- 1. 黑龙江省中医药科学院医学部肾病科,哈尔滨 150000,黑龙江
- 2. 黑龙江省齐齐哈尔市第一医院,齐齐哈尔 161000,黑龙江
- 3. 北京中医医院顺义医院,北京 101300
- 折叠
摘要
核受体(nuclear receptors,NRs)是维持肾脏脂质平衡的关键,其功能障碍通过促进肾脏脂质蓄积而在很大程度上导致了糖尿病肾病(diabetic nephropathy,DN)的进展.然而,现代医学中很少有通过调节NRs来有效抑制肾脏脂质蓄积的疗法.本文概述NRs介导的DN肾脏脂质蓄积的最新进展,然后,总结近年来有关中药对DN的作用和机制的研究,并强调中药通过NRs对肾脏脂质蓄积的作用.此外,还分析了中药通过NRs介导的肾脏脂质蓄积治疗DN的优势和局限性,强调通过NRs调节肾脏脂质蓄积是治疗DN的一种有前景的治疗策略.
Abstract
Dysfunction of nuclear receptors(NRs),which are critical for maintaining renal lipid homeostasis,largely contributes to the progression of diabetic nephropathy(DN)by promoting renal lipid accumulation.However,there are few thera-pies in modern medicine that effectively inhibit re-nal lipid accumulation by modulating NRs.In this review,we first summarize recent advances in NRs-mediated renal lipid accumulation in DN.Then,we summarize recent studies on the effects and mech-anisms of Chinese herbal medicines on DN and highlight the effects of Chinese herbal medicines on renal lipid accumulation via NRs.In addition,the advantages and limitations of traditional Chi-nese medicine in the treatment of DN via NRs-me-diated renal lipid accumulation are analyzed,and the modulation of renal lipid accumulation via NRs is emphasized as a promising therapeutic strategy for the treatment of DN.
关键词
核受体/糖尿病肾病/脂质沉积/中药复方Key words
nuclear receptors/diabetic nephropa-thy/lipid accumulation/Chinese herbal medicine引用本文复制引用
基金项目
国家自然科学基金(82274489)
北京市自然科学基金(7232326)
出版年
2024
国家科技期刊平台
NSTL
万方数据