Advances in diagnosis,treatment and management of hypertriglycer-idemia in pregnancy
Hypertriglyceridemia(HTG)during pregnancy may cause serious complications such as acute pancreatitis,gestational diabetes mellitus,and preeclampsia,especially the high mortality rate of maternal acute pancreatitis is of concern.The physiologic increase in triglyceride(TG)levels during pregnancy poses a challenge for the diagno-sis of HTG,there are no diagnostic criteria for preg-nant women.The management of HTG in pregnan-cy remains focused on early screening and a scien-tifically based fat-restricted diet.Omega-3 fatty ac-id therapy may be considered for those who can-not be controlled after strict dietary restriction and lifestyle changes,and fibrates may be used in late pregnancy when the benefits outweigh the risks,as appropriate,and plasma exchange may be a safe and effective option for extremely severe patients.TG levels in early pregnancy are associated with maternal postpartum and neonatal prognosis.Fur-ther studies on pharmacologic treatments and management for HTG in pregnancy are expected.
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