Advancements in the application of biologics for rheumatic autoim-mune diseases in pregnancy
Rheumatic autoimmune diseases are chronic conditions affecting multiple systems,pre-dominantly occurring in young women of childbear-ing age.Given the nature of diseases and unique physiological changes during pregnancy,they may adversely impact pregnancy outcomes and endan-ger maternal and fetal health.In recent years,with the deepening of immunological research,biologi-cally targeted therapy has gradually become a fo-cus of attention in the treatment of rheumatic au-toimmune diseases in pregnancy.Biologics effec-tively alleviate disease symptoms,mitigate preg-nancy complications,and improve adverse preg-nancy outcomes by targeting pivotal inflammatory factors.The review systematically discusses the structure and pharmacokinetic characteristics of bi-ologics,and comprehensively reviews the current application and future prospects in managing rheu-matic autoimmune diseases in pregnancy based on their specific targets.It aims to provide scientific references and guidance on the safe administration of medications and therapeutic strategies for these patients,ultimately enhancing health outcomes for mothers and infants.
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