Correlation between vitamin D levels and urinary incontinence in women with type 2 diabetes mellitus
AIM:To investigate the correlation be-tween vitamin D levels and urinary incontinence in women with type 2 diabetes mellitus(T2DM).METHODS:A total 366 female T2DM patients who were hospitalized in Department of Endocrinology,First Hospital of Lanzhou University from May 2022 to July 2023 were selected and were classified as vi-tamin D deficiency(＜20 ng/mL),insufficiency(20-30 ng/mL),and sufficiency(＞30 ng/mL)according to serum 25-hydroxyvitamin D[25(OH)D]concen-tration.The prevalence of urinary incontinence and severity was compared among three groups.Ad-justed logistic regression was used to analyze the correlation between vitamin D levels and urinary in-continence and its subtypes.RESULTS:Of the 366 patients,174(47.5％)T2DM with urinary inconti-nence.25(OH)D level was significantly lower in group with urinary incontinence than without(11.9 ng/mL vs.17.8 ng/mL,P＜0.01).The prevalence of urinary incontinence and moderate and severe uri-nary incontinence was significantly higher in group with vitamin D deficiency than groups with insuffi-ciency and sufficiency(P＜0.05).Adjusted logistic re-gression analysis showed that vitamin D deficiency was associated with an increased risk of any incon-tinence and urgency incontinence compared to vi-tamin D sufficiency(P＜0.05),vitamin D insufficien-cy was not associated with urinary incontinence.Age,BMI,parity and low 25(OH)D levels were inde-pendent risk factors for combined urinary inconti-nence in women with T2DM.CONCLUSION:Vita-min D deficiency is significantly associated with the risk of urinary incontinence in women with T2DM,and appropriate vitamin D supplementation may have some benefits for urinary incontinence.
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