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免疫检查点抑制剂相关急性心肌梗死病例分析

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免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)作为治疗肿瘤的重要药物,显著延长恶性肿瘤患者生存期.同时,免疫相关不良反应也逐渐增多;其中,ICIs存在增加急性冠脉事件的发生风险,但目前临床报道少见.本文通过1例肺小细胞神经内分泌癌患者使用ICIs后出现急性心肌梗死的病史资料分析,提示临床医生应警惕ICIs相关急性心肌梗死的发生,通过早期识别、及早干预改善患者不良预后.
A case of immune checkpoint inhibitor associated acute myocardial infarction
As an important advance in the treatment of anti-tumor therapy,immune checkpoint inhibitors significantly prolong the survival of patients with malignant tumors.At the same time,immune-related adverse reactions are also increasing,among which ICIs have increased the risk of acute coronary events,but clinical reports are rare.This paper analyzes the history of a patient with pulmonary small cell neuroendocrine carcinoma who developed acute myocardial infarction after ICIs treatment,suggesting that clinicians should be alert to the occurrence of ICIs-related acute myocardial infarction,and improve the prognosis of patients through early identification and intervention.

immune checkpoint inhibitoracute myocardial infarctionlung cancer

徐冉、陆浩、王妍、程蕾蕾

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复旦大学附属中山医院心内科,上海 200032

上海市心血管病研究所,上海 200032

复旦大学附属中山医院肿瘤内科,上海 200032

复旦大学附属中山医院心脏超声诊断科,上海 200032

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免疫检查点抑制剂 急性心肌梗死 肺癌

国家自然科学基金国家自然科学基金

8217035982300299

2024

中国临床医学
复旦大学附属中山医院

中国临床医学

CSTPCD
影响因子:1.002
ISSN:1008-6358
年,卷(期):2024.31(4)