The differential diagnostic value of left ventricular segmental myocardial strain in cardiac amyloidosis and non-obstructive hypertrophic cardiomyopathy
Objective To explore the difference of the left ventricular global longitudinal strain(GLS)and the segment strains between cardiac amyloidosis(CA)and non-obstructive hypertrophic cardiomyopathy(HCM).Methods Twenty patients with immunoglobulin light chain cardiac amyloidosis(AL-CA)as CA group and 20 patients with non-obstructive HCM selected as controls(HCM group)were enrolled from January 2016 to April 2022 in Zhongshan Hospital,Fudan University.All patients underwent two-dimensional speckle tracking echocardiography(2D-STE).The left ventricle GLS and the segmental strains were calculated.The values of these strains to distinguish AL-CA from HCM were analyzed by receiver operating characteristic(ROC)curves and logistic regression analysis.Results In the CA group,the GLS parameters(3P,4Ch,2Ch,3Ch),as well as the left ventricle segmental strains(MID-ANT/LAT,MID-INF/SEPT,BASAL-ANT/LAT,BASAL-INF/SEPT,MID-ANT,MID-INF,BASAL-ANT,BASAL-INF,MID-INF/LAT,BASAL-ANT/SEPT,and BASAL-INF/LAT)were all lower than those in the HCM group(P＜0.01).ROC results showed that GLS(4Ch),GLS(2Ch),GLS(3Ch),GLS(3P),BASAL-ANT/LAT,BASAL-INF/SEPT,BASAL-ANT,BASAL-INF,BASAL-ANT/SEPT and BASAL-INF/LAT had good efficacy in distinguishing AL-CA from HCM.Logistic regression analysis showed that BASAL-ANT/LAT was an independent factor in distinguishing AL-CA from HCM(P＜0.01).The consistency of test results was good.Conclusions The left ventricular segmental myocardial strains show good efficacy in distinguishing AL-CA from HCM,and BASAL-ANT/LAT has highest application value.
万方数据
维普
