Comparison of reflux characteristics between grade A and grades B/C reflux esophagitis based on esophageal pH-impedance monitoring
Objective To compare the reflux characteristics between reflux esophagitis(RE)patients with Los Angeles(LA)classification grade A and grades B/C based on esophageal pH-impedance monitoring results.Methods A total of 74 RE patients at Zhongshan Hospital(Xiamen Branch),Fudan University from June 2021 to June 2024 were enrolled,and were divided into the LA-A group(n=46)and the LA-B/C group(n=28)based on the endoscopic diagnosis results.The general clinical data,symptom questionnaire score,and esophageal 24-hour pH-impedance monitoring results were compared between the two groups.Results There were no statistically significant differences in demographic data and the response rate of acid suppression therapy between the two groups.24-hour esophageal pH-impedance monitoring results showed that there were no statistically significant differences in upright,supine,and total reflux indices,including reflux episodes,acid exposure time(AET),AET percentage(AET%),long acid reflux episodes,longest reflux duration,and total DeMeester score between the two groups.There were no statistically significant differences in distal reflux episodes,proximal reflux episodes,and high reflux(acid,weak acid,and non-acidic reflux)episodes,mean nocturnal baseline impedance(MNBI)between the two groups.The rates of pathological reflux(AET%≥6%)in LA-A group and LA-B/C group were 67.4%and 71.4%,respectively;there were no statistically significant differences in the ratio of AET%composition and the count of impedance reflux exceeding 80 during 24 h between the two groups.Conclusions LA-A grade RE based on the endoscopic diagnosis facilitates the identification of gastroesophageal reflux disease in the Chinese population
万方数据
维普
