Application of contrast-enhanced ultrasound in differential diagnosis of≤3 cm hepatocellular carcinoma and focal nodular hyperplasia of the liver
Objective To investigate the diagnosis value of contrast-enhanced ultrasound(CEUS)in the differentiation of hepatocellular carcinoma(HCC)and focal nodular hyperplasia(FNH)of the liver with≤3 cm of maximum diameter.Methods The image characteristics in 48 lesions of HCC with maximum diameter≤3 cm and 48 lesions of FNH with maximum diameter≤3 cm confirmed by pathology were retrospectively analyzed.The phase changes,enhancement patterns and enhancement characteristics of the lesions in the two groups were compared.Results All lesions in the two groups showed high-echo in the arterial phase.The contrast arrival time in HCC group and FNH group was 17(15,19)s and 15(12,18.75)s(P=0.017);the peak time in the two groups was 21(17,25)s and 22(19,26)s(P＞0.05).The main enhancement patterns of HCC group and FNH group in arterial phase were homogeneous enhancement and centrifugal enhancement,respectively.All HCC lesions showed homogeneous enhancement,which was significantly higher than FNH(2.08%,P＜0.05);97.91%of FHN lesions showed centrifugal enhancement,which was higher that of HCC lesions(0,P＜0.05).During the CEUS process,87.5%of HCC lesions showed"rapid fill-in and rapid wash-out",which was significantly higher than that of FNH lesions(8.33%,P＜0.05);91.67%of FNH lesions showed"rapid fill-in"and"synchronous/slow wash-out"which was significantly higher than that of HCC lesions(12.50%,P＜0.05).Conclusion CEUS is helpful in the differential diagnosis of FNH and HCC with maximum diameter≤3 cm.
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