Objective:To explore the correlation between CT perfusion(CTP)parameters and establishment of collateral cir-culation and prognosis of interventional therapy in acute ischemic stroke(AIS).Methods:Eighty-two patients with AIS admitted to the hospital from October 2020 to October 2022 were enrolled.With CT angiography(CTA)as the diagnostic"gold stan-dard",the patients were divided into good group(15 cases),general group(38 cases)and poor group(29 cases)according to the establishment status of collateral circulation.All patients underwent CTP examination.CTP parameters(cerebral blood volume(CBV),cerebral blood flow(CBF),mean transit time(MTT),time to peak(TTP))were compared among the three groups,and the evaluating value of the above CTP parameters on AIS collateral circulation was analyzed by receiver operating characteristic(ROC)curve,and the correlation between CTP parameters and collateral circulation grading was analyzed.National Institutes of Health Stroke Scale(NIHSS)and modified Ranking Scale(mRS)were used to evaluate the prognosis of interventional therapy in patients with AIS,and Pearson correlation analysis was adopted to analyze the correlation between CTP parameters and prog-nosis.Results:CBV and CBF were shown as good group＞general group＞poor group(P＜0.05).MTT and TTP were manifested as good group＜general group＜poor group(P＜0.05).ROC curve analysis showed that CBV,CBF,MTT,TTP and combined detection had certain efficiency on evaluating AIS collateral circulation establishment(P＜0.05),and their areas under the curves were 0.640,0.672,0.654,0.664 and 0.896 respectively.Combined detection had the highest efficiency,with sensitivity of 84.09％and specificity of 92.11％.Spearman correlation analysis found that CBV and CBF were positively correlated with collateral circulation grading(P＜0.05),and MTT and TTP were negatively correlated with collateral circulation grading(P＜0.05).NIHSS score and mRS score were showed as good group＜general group＜poor group(P＜0.05).Pearson correlation analysis found that CBV and CBF were negatively correlated with NIHSS score and mRS score in patients with AIS(P＜0.05),and MTT and TTP were positively correlated with NIHSS score and mRS score(P＜0.05).Conclusion:Among CTP parameters,CBV and CBF are positively correlated with AIS collateral circulation grading and prognosis of interventional therapy,and MTT and TTP are neg-atively correlated with AIS collateral circulation grading and prognosis of interventional therapy.CTP parameters can be used to evaluate the establishment of collateral circulation and prognosis of interventional therapy.
维普
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