Objective:To investigate the functional connectivity(FC)of anterior cingulate gyrus in type 2 diabetes(T2DM)without mild cognitive impairment using resting state functional MRI(rs-fMRI).Methods:Fifty-six patients with T2DM and demographic data matched 60 healthy subjects(HC)were enrolled in this study.All participants underwent rs-fMRI and neu-ropsychological assessment.The whole brain FC analysis was performed using different subregions of anterior cingulate gyrus as seed points.The correlation analysis between FC values in different brain regions and clinical data and neuropsychological evaluation was conducted.Results:Compared with HC,T2DM patients without MCI had lower FC values in the pregenual an-terior cingulate cortex(pACC BA32)and bilateral hippocampus,and higher FC values in the bilateral lateral prefrontal lobe and left central anterior gyrus(P＜0.05).There was a negative correlation between the pACC(BA32)and the left hippocampus FC intensity and color trails test-2(CTT-2)score in T2DM group(P=0.002,r=-0.410).Conclusion:The disorder of FC of pACC(BA32)and bilateral hippocampus and bilateral lateral prefrontal lobe in T2DM patients without MCI suggests that there may be a compensatory mechanism involving memory function in T2DM patients.
维普
万方数据