Objective:To analyze the diagnostic value of 4D color Doppler ultrasound combined with peak systolic flow velocity/end-diastolic flow velocity(S/D)of umbilical blood flow in late pregnancy for fetal growth restriction.Methods:112 pregnant women diagnosed with fetal growth restriction in our hospital from November 2019 to November 2020 were selected as the study group,and another 88 normal pregnant women who underwent pregnancy testing in our hospital were selected as the control group.All pregnant women underwent 4D color Doppler ultrasonography and S/D value of umbilical cord blood flow in late pregnancy.Results:Compared with the control group,the S/D value of the research group was higher at 28~32 weeks and>32 weeks(P<0.05).Compared with the good prognostic fetus in the study group,the S/D value of the foetus with poor prognostic was higher at 28~32 weeks and>32 weeks(P<0.05).Compared with the control group,the blood flow index(FI),vascularization index(VI)and vascularization blood flow index(VFI)levels of the study group were lower at 28~32 weeks and>32 weeks(P<0.05).Compared with fetuses with good prognosis in the study group,FI,VI and VFI levels of fetuses with poor prognosis at 28~32 weeks and>32 weeks were lower(P<0.05).ROC curve showed that the diagnostic value of the two combined methods for fetal growth restriction was higher than that of 4D color Doppler ultrasound and the single detection of umbilical cord blood flow S/D value in late pregnancy(P<0.05).Conclusion:In pregnant women with fetal growth restriction,S/D value of umbilical cord blood flow in late pregnancy was higher,and Fl,VI and VFI levels of four-dimensional color Doppler ultrasound parameters were lower,and S/D value of umbilical cord blood flow in late pregnancy of fetuses with poor prognosis was higher than that of fetuses with good prognosis,while FI,VI and VFI levels were lower than that of fetuses with good prognosis.4D color Doppler ultrasound combined with umbilical cord blood flow S/D value in late pregnancy has high diagnostic value for fetal growth restriction.