Objective:To evaluate the diagnostic value of high-frequency ultrasound imaging combined with shear wave e-lastography(SWE)for carpal tunnel syndrome.Methods:Ninety-eight patients with carpal tunnel syndrome admitted to our hos-pital from April 2020 to October 2022 were enrolled,and another 50 healthy individuals who underwent physical examination during the same period were selected as control group.All subjects were examined using SWE and high-frequency ultrasound.The high-frequency ultrasound parameters(anteroposterior(D 1)and transverse(D2)diameters of the median nerve taken bilaterally at pisiform bone level,the corresponding cross-sectional area(CSAl,CSA2),as well as the SWE parameters(anteroposterior(W)and transverse(F)elastic modulus of the median nerve taken bilaterally at pisiform bone level,strain ratio between the median nerve and flex or superficialis digitorum muscle(FRatio))were compared between two groups.Then receiver operating character-istic(ROC)curve was plotted to evaluate the diagnostic efficacy of separate and combined detection of high-frequency ultra-sound and SWE parameters in carpal tunnel syndrome.Results:D1 and CSA1 values in carpal tunnel syndrome group were significantly higher than those in control group(P<0.05),while no statistical difference was found in D2 and CSA2 values(P>0.05).The values of W,F and FRatio in carpal tunnel syndrome group were significantly higher than those in control group(P<0.05).ROC curve denoted that the AUC of D1,CSA1,W,F and FRatio for the diagnosis of carpal tunnel syndrome was 0.698,0.772,0.773,0.719 and 0.702 respectively,and the AUC of combined examination of above parameters was 0.864,with the sensitivity and specificity of 90.8%and 76.0%,indicating that the diagnostic value of combined test was higher than that of separate test.Conclusion:High frequency ultrasound imaging combined with SWE can accurately reflect the median nerve stiffness in patients with carpal tunnel syndrome,providing an easy and noninvasive way for clinical diagnosis,which is of great value.