Objective:To explore the value of quantitative diagnosis of thigh muscles in dermatomyositis/polymyositis(DM/PM)patients with polymyositis by MAGiC sequence combined with asymmetric acquisition technique and iterative least-squares estimation quantitation sequence(IDEAL-IQ).Methods:A total of 67 patients with PM/DM confirmed clinically and pathologi-cally in the General Hospital of Ningxia Medical University(case group)and 23 volunteers matched by age,sex and body mass index(BMI)(control group)were retrospectively collected.A Signa Architect 3.0T scanner was used to perform double thigh MAGiC sequence,IDEAL IQ sequence and conventional T1WI,T2WI and T2Flex sequence scanning.T2 values,T,values,PD values,FF values and R2*values of 12 muscles(tensor fascia lata,sartorius,quadriceps,adductor magnus,adductor longus,gracilis,semimembranosus,semitendinosus,biceps femoris)were measured independently in the double-blind method by two radiologists on each sequence.The T2 values,T,values,PD values,FF values and R2*values of different groups were com-pared by one-way ANOVA.The diagnostic efficacy of T2 value,PD value,FF value and R2*value and the combination of T2 value and FF value in DM/PM was analyzed by receiver operating characteristic(ROC)curve.Results:①The T2 val ue of DM/PM case group was higher than that of the control group(Z=-19.818,P＜0.05).The FF value of the case group was higher than that of control group(Z=-14.586,P＜0.05).PD value of case group was lower than that of control group(Z=-6.803,P＜0.05).The R2*value of the case group was lower than that of the control group(Z=-5.475,P＜0.05).There was no significant difference in T1 values between the case group and the control group(Z=-0.936,P=0.349).②The AUC of T2 value is 0.902(0.880～0.925),FF value is 0.817(0.786 6～0.848),PD value is 0.653(0.613-0.694),and R2*value is 0.712(0.674 4～0.750).P＜0.05.③The AUC of T2 value combined with FF value was 0.934(0.917～0.951),P＜0.05.Conclusion:MAGiC quantitative atlas can quantify the degree of thigh muscle edema in DM/PM patients.IDEAL IQ sequence can quantify thigh fat infiltration.
维普
万方数据