Objective:To analyze and summarize the clinical features and imaging findings of Rosai-Dorfman disease(RDD)in order to improve the diagnosis of the disease.Methods:The clinical and imaging features of 17 cases of RDD confirmed by pathology were analyzed retrospectively.There were 12 males and 5 females,aged 12 to 71 years old.Results:The lesions were located in the head and neck(9 cases),chest(6 cases),abdomen(1 case)and lower extremity(1 case).We found that the pathogenesis of some RDD was closely related to IgG4 and other immune-related diseases or lymphoma.The imaging findings of RDD were homogeneous soft tissue density/signal,no necrosis and cystic degeneration,moderate diffusion restriction and high 18F-FDG uptake.The imaging findings of RDD in the central nervous system and non-central nervous system were different.We identified 3 rare cases,intracranial-extracranial noncommunicating RDD,mixed RDD with systemic involvement of glands and lymph nodes,and RDD of the liver with MR appearance similar to"hepatocellular carcinoma".Conclusion:RDD occurs in a wide range of sites and imaging manifestations vary.Understanding the common characteristics and differences of RDD is helpful to strengthen the diagnosis and differential diagnosis of this disease.
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