Objective:To investigate the value of ultrasound gray scale ratio(UGSR)in differentiating clear cell renal cell carcinoma(ccRCC)and renal angiomyolipoma(RAML)(≤4 cm).Methods:The ultrasound imaging data from 101 cases of ccRCC and 98 cases of RAML(≤4 cm)were retrospectively analyzed.The ultrasound gray scale of the lesions,renal cortex and renal sinus were measured using the RADinfo system with c-UGSR(ultrasound gray scale of lesion/ultrasound gray scale of renal cortex)and s-UGSR(ultrasound gray scale of lesion/ultrasound gray scale of renal sinus)calculated.The optimal thresholds for c-UGSR and s-UGSR were calculated and the diagnostic efficacy of the combined diagnosis was assessed via plotting the re-ceiver operating characteristic(ROC)curve.The consistency of UGSR between the two subjects was analyzed by interclass cor-relation coefficient(ICC).Results:The values of c-UGSR were 1.170(0.890,1.430)and 1.840(1.458,2.283)for ccRCC and RAML lesions,respectively(Z=-8.666,P＜0.05),and the values of s-UGSR were 0.680(0.500,0.825)and 1.090(0.878,1.248)for ccRCC and RAML lesions,respectively(Z=-8.585,P＜0.05).The area under the ROC curve(AUC)by c-UGSR and s-UGSR analysis for ccRCC was 0.856 and 0.852 respectively,with optimal thresholds of 1.67 and 0.85,and the sensitivity and speci-ficity of 92.1%and 63.3%,80.2%and 78.6%,respectively.The AUC of the combined diagnosis by c-UGSR and s-UGSR for ccRCC was 0.884,with sensitivities and specificities of 85.2%and 80.6%,respectively.The combined diagnostic efficacy was superior compared with individual ones(Z=2.016,2.467,both P＜0.05).Good consistency was observed between the two subjects for c-UGSR,s-UGSR(ICC=0.810,0.845,both P＜0.05).Conclusion:With strong reproducibility,the UGSR can evaluate ccR-CC and RAML(≤4 cm)more objectively and accurately.
万方数据