Objective:To investigate the value of CT perfusion combined with MRI in evaluating the ischemic penumbra of acute cerebral infarction.Methods:The whole brain CT perfusion and MRI examination results of 152 patients with acute cerebral infarction who were admitted to the hospital from January 2020 to January 2022 were analyzed retrospectively.The value of CT perfusion and MRI in evaluating the ischemic penumbra of acute cerebral infarction was analyzed.Results:Cere-bral blood volume(CBV)and cerebral blood flow(CBF)in the core infarction area were lower than those in corresponding area on the healthy side,while the mean transit time(MTT)and time to peak(TTP)were longer than those in corresponding area on the healthy side(P＜0.05).CBV in the ischemic penumbra and corresponding area on the healthy side was similar.CBF in the ischemic penumbra was lower than that in corresponding area on the healthy side,while MTT and TTP were longer than those in corresponding area on the healthy side(P＜0.05).CBV and CBF in the ischemic penumbra were significantly higher than those in the core infarction area,while MTT and TTP were shorter than those in the core infarction area(P＜0.05).There was no statistically significant difference in the apparent diffusion coefficient(ADC)value between the ischemic penumbra and corresponding area on the healthy side(P＞0.05).There was a statistically significant difference in ADC value between the core infarction area and corresponding area on the healthy side(P＜0.05).The rADC value of the ischemic penumbra was signifi-cantly higher than that of the core infarction area(P＜0.05).Among CT perfusion parameters,the highest AUC,sensitivity and specificity for diagnosing and distinguishing ischemic penumbra were 0.992,97.37％and 96.71％,respectively.Among MRI pa-rameters,the highest AUC,sensitivity and specificity for diagnosing and distinguishing ischemic penumbra were 0.688％,73.68％and 56.58％,respectively.The AUC of CT perfusion parameters combined with MRI for evaluating the ischemic penumbra of acute cerebral infarction was 0.999(0.986～1.000),and Youden index was 0.980.When the critical value was 0.238,the sensitivity and specificity were 100.00％and 98.03％.Conclusion:The combination of CT perfusion and MRI is effective in evaluating the ischemic penumbra of acute cerebral infarction,with good sensitivity and specificity,and is worthy of clinical promotion.
维普
万方数据