Objective:To apply two-dimensional ultrasound(US)combined with superb microvascular imaging(SMI)and CD-FI to compare the distribution and characteristics of blood vessels in thyroid nodules,and to explore the diagnostic value of SMI and CDFI in benign and malignant thyroid nodules.Methods:SMI and CDFI images of 202 patients with thyroid nod-ules admitted to the First Affiliated Hospital of Jinzhou Medical University from April 2021 to September 2021 were collected,and TI-RADS classification was performed and compared with postoperative pathology,and statistical analysis was conducted to analyze the sensitivity and specificity of 2D ultrasound combined with SMI and 2D ultrasound combined with CDFI in the diagnosis of thyroid nodules,ROC curve was drawn,and the area under the curve(AUC)was compared.Results:The sensitiv-ity and AUC of US combined SMI diagnosis were 92.5%and 0.928 respectively.The sensitivity of US combined with CDFI was 88.2%and AUC was 0.854.The difference was statistically significant(P<0.05).Conclusion:SMI can more accurately dis-play the blood flow distribution and morphology of thyroid nodules,and can better reflect the different characteristics of be-nign and malignant nodules,so as to improve the diagnostic value of thyroid nodules.Moreover,the combination with TI-RADS classification can significantly improve the diagnostic rate of malignant thyroid nodules,which has important clinical sig-nificance.