18F-FDG PET/CT对偶发性进展期结直肠腺瘤的诊断价值
The diagnostic value of 18F-FDG PET/CT in the sporadic advanced colorectal adenoma
徐妮娜 1彭雨诗 2唐栋 1戚正伟 3丁建平 1唐坤2
作者信息
- 1. 杭州师范大学附属医院放射科,浙江 杭州 310000
- 2. 温州医科大学附属第一医院核医学科,浙江 温州 325000
- 3. 浙江大学医学院附属邵逸夫医院消化内科,浙江 杭州 310000
- 折叠
摘要
目的:18F-FDG PET/CT最大标准摄取值(SUVmax)与进展期结直肠腺瘤的关系尚不明确.本研究旨在探讨 18F-FDG PET/CT的SUVmax鉴别进展期及非进展期结直肠腺瘤的能力.方法:回顾性分析 153 例经 18F-FDG PET/CT偶然发现的结直肠腺瘤患者的资料,根据癌化风险分为进展期和非进展期结直肠腺瘤两组.术前PET/CT测量病灶的SUVmax,采用受试者工作特性(ROC)曲线分析确定两组的最佳截断值.纳入常规的临床特征,采用Logistic回归模型进行单因素和多因素分析确定独立危险因素.结果:进展期和非进展期两组结直肠腺瘤患者的SUVmax分别为 8.61±4.01、5.02±2.00,差异有统计学意义(P<0.05),Logistic多因素回归分析显示SUVmax、CEA、CA125 和隐血是预测进展期结直肠腺瘤的独立危险因素.单SUVmax检测的曲线下面积(AUC)为 0.810,SUVmax联合CEA、CA125 及隐血检测的AUC为 0.879.结论:基于 18F-FDG PET/CT成像的SUVmax是预测进展期结直肠腺瘤的独立危险因素,可以作为一种无创的定量诊断工具,有助于术前指导治疗策略的制定.
Abstract
Objective:The relationship between the maximum standardized uptake value(SUVmax)of 18F-FDG PET/CT and the advanced colorectal adenoma remains unclear.The purpose of this study was to investigate the diagnostic performance of SUVmax in differentiating advanced and non-advanced colorectal adenomas.Methods:This study enrolled 153 patients with colorectal adenoma accidentally diagnosed by 18F-FDG PET/CT.According to the risk of carcinogenesis,the patients were di-vided into two groups with advanced and non-advanced colorectal adenoma.Focal SUVmax of PET/CT was measured.The re-ceiver operating characteristic(ROC)curve was used to determine the optimal cut-off values for the two groups.Univariate and multivariate analyses were performed using Logistic regression models to identify independent risk factors.Results:There was statistical significance between SUVmax values of the advanced and non-advanced colorectal adenoma groups(8.61±4.01 vs.5.02±2.00,P<0.05).Logistic multivariate regression analysis showed that SUVmax,CEA,CA125 and occult blood were the in-dependent risk factors.The area under the curve(AUC)of SUVmax was 0.810,and the AUC of the combination of SUVmax,CEA,CA125 and occult blood was 0.879.Conclusions:The SUVmax value based on 18F-FDG PET/CT imaging is an inde-pendent risk factor for predicting advanced colorectal adenoma,which can be used as a non-invasive quantitative diagnostic tool to guide preoperative treatment strategies.
关键词
结直肠肿瘤/正电子发射断层显像计算机体层摄影术/氟脱氧葡萄糖F18Key words
Colorectal Neoplasms/Positron Emission Tomography Computed Tomography/Fluorodeoxyglucose F18引用本文复制引用
基金项目
浙江省医药卫生科技计划基金资助项目(2020KY708)
出版年
2024
国家科技期刊平台
NSTL
万方数据