摘要
目的:通过扩散谱成像(Diffusion spectrum imaging,DSI)及图论分析探究 2 型糖尿病(T2DM)患者脑网络全局拓扑属性改变及其与相关临床指标和认知功能评分的相关性.方法:收集符合诊断标准的 27 例T2DM患者(T2DM组)及招募性别、年龄、受教育年限相匹配的 19 例健康志愿者(HC组),采用认知量表等检测受试者MoCA、VFT、焦虑相关评分,并收集空腹血糖、甘油三酯、高密度脂蛋白等临床指标.均使用 3.0T MRI行DSI扫描,通过DSI-STUDIO软件构建全脑结构网络并计算全局网络拓扑属性.分析两组被试脑网络全局拓扑属性的差异,将年龄、性别作为协变量,采用spearman偏相关分析评估T2DM患者脑结构网络相关特征参数与临床相关指标及认知评分的相关性,以P＜0.05 为差异具有统计学意义.结果:T2DM组的小世界系数、全局效率、聚类系数及富人俱乐部(rich-club)系数(k=5、15)均低于HC组(P＜0.05),而T2DM组特征路径长度高于HC组(P＜0.05).此外,rich-club系数(k=5)与焦虑呈负相关(r=-0.630,P=0.001),rich-club系数(k=15)与FPG呈负相关(r=-0.398,P=0.049).结论:T2DM患者小世界系数、全局效率及聚类系数的全局传输能力均显示下降并伴纤维富集区域损伤,其中焦虑及空腹血糖的改变可能与全局拓扑属性之间存在一定关联.
Abstract
Objective:To explore the changes in global topological properties of brain networks in type 2 diabetes melli-tus(T2DM)patients and their correlation with relevant clinical indicators and cognitive function scores through diffusion spec-troscopy imaging(DSI)and graph theory analysis.Methods:Twenty-seven T2DM patients with mild(T2DM group)who met the diagnostic criteria and 19 healthy volunteers(HC group)who matched gender,age,and years of education were recruited.Mo-CA,VFT,anxiety related scores,and clinical indicators such as fasting blood glucose,triglycerides,and high-density lipopro-tein were measured using cognitive scales.All DSI scans were performed by a 3.0T MRI(Siemens,Magnetom Skyra),and the whole brain structure network was constructed using DSI-STUDIO software to calculate the global network topology properties.We analyzed the differences in global topological properties of brain networks between two groups of participants,using age and gender as covariates.Spearman partial correlation analysis was used to evaluate the correlation between brain structural network related characteristic parameters and clinical related indicators and cognitive scores in T2DM patients.A difference of P＜0.05 is statistically significant.Results:The small world coefficient,global efficiency,clustering coefficient,and rich club coefficient(k=5,15)of the T2DM group were lower than those of the HC group(P＜0.05),while the feature path length of the T2DM group was higher than that of the HC group(P＜0.05).In addition,the rich club coefficient(k=5)is negatively correlated with anxiety(r=-0.630,P=0.001),and the rich-club coefficient(k=15)is negatively correlated with FPG(r=-0.398,P=0.049).Conclusion:The global transmission ability of small world coefficient,global efficiency,and clustering coefficient in T2DM patients all showed a decrease accompanied by damage to fiber rich regions.Anxiety and changes in FPG may be associated with global topological attributes.
维普
万方数据