摘要
目的:对比分析甲状腺微小乳头状癌(PTC)与非微小癌超声造影特征差异.方法:回顾性分析 2021 年 9 月—2023年 3 月我院经手术或穿刺病理确诊的PTC患者 96 例(共 101 枚结节),按照肿瘤最大直径分成PTC组(最大直径≤10 mm)和非微小癌组(最大直径＞10 mm),比较两组结节超声造影增强程度、增强方式、增强均匀性,分析两组超声造影定量参数的差异.结果:不同大小的PTC超声造影增强程度、增强方式、增强均匀性差异均存在统计学意义(P＜0.05),PTC组向心性增强、等增强较非微小癌组多见,非微小癌组偏心性、弥漫性增强、低增强及高增强较PTC组多见.PTC组均匀性增强多见,非微小癌组不均匀性增强多见.两组超声造影定量参数上升时间(RT)、平均渡越时间(mTT)、下降时间(FT)差异有统计学意义(P＜0.05),PTC组的RT、mTT、FT均高于非微小癌组,两组的达峰时间(TTP)、峰值强度(PE)、流入相比率(WiR)、流出相比率(WoR)、流入相灌注指数(WiPI)、流入相曲线下面积(WiAUC)、流出相曲线下面积(WoAUC)、流入相和流出相曲线下面积(WiWoAUC)差异无统计学意义.结论:PTC超声造影表现多以向心性、不均匀低增强为主,不同大小PTC具有不同的超声造影表现,临床诊断中需加以考虑.
Abstract
Objective:To compare and analyze the differences in contrast enhanced ultrasound features between papillary thyroid microcarcinoma and non-microcarcinoma.Methods:A retrospective analysis was conducted on 96 patients(101 nodules)with papillary thyroid carcinoma diagnosed by surgery or puncture pathology at the People's Hospital of Guangxi Zhuang Au-tonomous Region from September 2021 to March 2023.They were divided into two groups based on the maximum diameter of the tumor:the papillary thyroid microcarcinoma group(maximum diameter≤10 mm)and the non-microcarcinoma group(maximum diameter＞10 mm).The degree,mode and uniformity of contrast enhanced ultrasound enhancement were compared between the two groups.Analyze the differences in quantitative parameters between two groups of contrast enhanced ultrasound.Results:There were statistically significant differences in the qualitative signs(including enhancement degree,enhancement mode and enhancement uniformity)of thyroid papillary carcinoma of different sizes(P＜0.05).The centripetal enhancement and isoenhance-ment were more common in the thyroid papillary microcarcinoma group than in the non-microcarcinoma group,while eccentric,diffuse enhancement,low enhancement and high enhancement were more common in the non-microcarcinoma group.Uniformity enhancement is more common in the papillary thyroid microcarcinoma group,while non-uniformity enhancement is more com-mon in the non-microcarcinoma group.As the nodules increase,eccentric and diffuse enhancement are more common.There was a statistically significant difference in the rise time(RT),mean transit time(mTT)and fall time(FT)of the quantitative pa-rameters of contrast enhanced ultrasound between the two groups.The time of RT,mTT and FT in thyroid papillary microcar-cinoma group was longer than that in non-microcarcinoma group.There was no statistically significant difference in the area under time to peak(TTP),peak enhancement(PE),wash-in rate(WiR),wash-out rate(WoR),wash-in perfusion index(WiPI),wash-in area under curve(WiAUC),wash-out AUC(WoAUC),wash-in and wash-out AUC(WiWoAUC)between the two groups.Conclusion:The contrast enhanced ultrasound manifestations of papillary thyroid carcinoma are mainly centripetal,uneven and low enhancement.Different sizes of papillary thyroid carcinoma have different contrast enhanced ultrasound manifestations,which need to be explored separately based on the size of the nodules.
基金项目
国家自然科学基金资助项目(82160339)
国家自然科学基金资助项目(81660292)
广西自然科学基金资助项目(2020GXNSFAA259014)
维普
万方数据