Objective:To investigate the guiding significance of intra-biliary contrast-enhanced ultrasound(IB-CEUS)in percutaneous transhepatic cholangial drainage(PTCD).Methods:Thirty-six patients who were to undergo PTCD were treated with ultrasound-guided catheterization.All patients underwent conventional ultrasound examination before catheterization,fol-lowed by another conventional ultrasound examination and IB-CEUS assessment after catheterization.Comparisons were made between the visualization range of the bile duct and the visualization rate of the drainage tube endpoint before and after IB-CEUS.Results:All patients were successfully catheterized under ultrasound guidance and the success rate of IB-CEUS was 100%.The visualization rates of primary bile duct by conventional ultrasound and IB-CEUS were both 100%(72/72),and the visualization rates of secondary bile duct were respectively 94%(135/144)and 97%(140/144).The percentage of 52%(151/288)and 96%(276/288)represented the visualization rates of tertiary bile duct by conventional ultrasound and IB-CEUS,severally.The visualization rate of IB-CEUS for catheter end was 100%(41/41),which was significantly better than that of conventional ultrasound(22%(9/41))(P<0.001).Conclusion:The results of IB-CEUS on the intrahepatic biliary and the drainage tube end-point are superior to those of conventional ultrasound examination,which can evaluate the effective drainage range of PTCD in real time and lay a solid foundation for assessing therapeutic effects.