Objective:To investigate the correlation between serum parathyroid hormone and high-frequency ultrasound features and 99mTc-MIBI SPECT/CT imaging semi-quantitative parameters T/NT in patients with hyperparathyroidism,suggesting the value of multiple imaging indicators combined in predicting the degree of hyperparathyroidism.Methods:A retrospective analysis was performed on 70 patients with hyperparathyroidism qualitatively diagnosed according to surgical pathology or guidelines and who underwent high-frequency ultrasound and 99mTc-MIBI SPECT/CT imaging.To evaluate the correlation of high-frequency ultrasound features,99mTc-MIBI SPECT/CT imaging semi-quantitative parameters T/NT and serum parathyroid hormone in patients with hyperparathyroidism,and to explore the predictive value of both on the degree of hyperparathy-roidism.Results:Among the 70 subjects,there was no significant difference in T/NT value and semi-quantitative blood flow score between primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism (SHPT) patients ( P>0.05).There was poor consistency between the number of diseased parathyroid glands detected by high-frequency ultrasound and serum PTH,and the correlation coefficients between serum parathyroid hormone(PTH) and the total volume of diseased glands,the semi-quanti-tative score of high-frequency ultrasound blood flow,and T/NT value were 0.289,0.460 and 0.453,respectively,with statisti-cal significance(P<0.05).There was no correlation between T/NT value and the total volume of the lesion and the semi-quanti-tative score of high-frequency ultrasound blood flow (P>0.05).Serum PTH=300 pg/mL was used as the cut-off value to judge the degree of hyperactivity as severe and non-severe,and ROC curves of gland volume,blood flow score and T/NT value were drawn:Gland volume,blood flow score,area under T/NT curve of 99mTc-MIBI SPECT/CT imaging were 0.824,0.831,0.702,sensitivity were 92.3％,80.8％,60.1％,specificity were 65.9％,68.2％,88.9％,respectively.The area under the com-bined diagnosis curve of the three indexes was 0.865,the sensitivity was 72.0％,and the specificity was 91.1％(P<0.05).Con-clusion:Pathological parathyroid volume,blood flow semiquantitative score and 99mTc-MIBI SPECT/CT imaging semiquantitative parameter T/NT value have good predictive value for serum PTH level increase,and the combination of multiple indicators can more accurately reflect the degree of pathological hyperparathyroidism,which can provide a beneficial supplement for the se-lection of treatment.
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