A comparative study of lung volume quantification between fibrotic interstitial lung disease and chronic obstructive pulmonary disease based on HRCT images
Objective:To compare the CT quantitative parameters reflecting the lesion involved lung volume in fibrotic in-terstitial lung disease(F-ILD) and chronic obstructive pulmonary disease(COPD),and to observe their correlation with lung func-tion indexes.Methods:The data of all patients were retrospectively analyzed.Including 76 patients with F-ILD,76 patients with COPD were matched with forced expiratory volume in one second(FEV1％) predicted value(predicted value within±1％) 1︰1,and 70 healthy controls were matched with age and sex.The differences and correlations between CT quantitative parame-ters and lung function parameters were analyzed.CT quantitative parameters included total lung volume,percentage of low at-tenuation area(LAA％),percentage of high attenuation area(HAA％) and percentage of total lung destruction area(DLA％),while lung function parameters included forced vital capacity(FVC％),FEV1％,total lung capacity(TLC％),carbon monoxide diffusion capacity(Dlco％) and comprehensive physiological index(CPI).The receiver operating characteristic(ROC) curve was used to ana-lyze the diagnostic efficacy of CT quantitative parameters based on visual assessment.Results:The lung function index FVC％pred was different between the groups.Dlco％pred and TLC％pred were different between F-ILD and COPD groups.Compared with the healthy control group,FEV1％pred was different between the groups(P<0.05).The whole lung volume in F-ILD group was significantly lower than that in other groups,HAA％ was significantly higher than that in other groups,LAA％ in COPD group was significantly higher than that in other groups,and DLA％ in healthy control group was significantly lower than that in other groups (all P<0.05).LAA％ and HAA％ had high sensitivity and specificity for the detection of emphysema and pul-monary fibrosis,respectively(LAA％:AUC=0.835;HAA％:AUC=0.934);HAA％ and DLA％ were negatively correlated with lung function indexes and positively correlated with CPI (all P<0.05).There was a significant negative correlation between DLA％ and Dlco％ in COPD group,F-ILD group and all patients(P<0.05).In the F-ILD group,DLA％ was positively correlated with CPI(P<0.05).Conclusions:Quantitative CT parameters LAA％,HAA％ and DLA％ are related to lung function,which can ob-jectively reflect the abnormal lung volume of patients with F-ILD and COPD.In addition,they have good diagnostic efficacy for emphysema and pulmonary fibrosis.
万方数据
维普
