Objective:To investigate and analyze the status of thyroid diseases of nuclear medicine workers,and provide a scientific basis for the development of radiation protection and health management for nuclear medicine occupational groups and the formulation of radiation protection standards. Methods:A questionnaire survey was conducted to collect thyroid-relat-ed information from nuclear medicine staff in various hospitals in Shaanxi Province from February to July 2023. The data in-cluded basic information,thyroid disease examination and diagnosis,and cognition of thyroid disease and radiation exposure protection. Three hundred and forty-two nuclear medicine staff were selected as analysis subjects,and the effects of factors such as age,gender,length of service in nuclear medicine,years of radiation exposure,cognition of radiation exposure and protection on thyroid diseases in practitioners were compared and analyzed. Results:①Among the analyzed subjects,124 nu-clear medicine workers had thyroid abnormalities (36.2%(124/342)),mainly manifested as thyroid nodules (22.8%(78/342)) and Hashimoto's disease (4.1%(14/342)). ②Compared with male staff,the prevalence of thyroid disease among female staff(40.3%(77/191) vs. 31.1%(47/151),P<0.05) was higher,while the prevalence of thyroid nodules (23.0%(44/191) vs. 22.5%(34/151),P>0.05) was not significantly different. ③The prevalence of thyroid disease and thyroid nodules increased with age,length of ser-vice in nuclear medicine work,and duration of radiation exposure (P<0.05). ④By multifactor regression analysis,age and sex (female) were identified as risk factors for thyroid disease(OR=1.046、1.694,95%CI:1.014~1.080、1.048~2.737,P<0.05). Con-clusion:Low-dose ionizing radiation in nuclear medicine environment may cause thyroid damage to the workers. Special atten-tion should be paid to radiation protection management for the females,workers of advanced age(long service) and more radia-tion exposure. Protection and management measures should be optimized to reduce the radiation exposure dose and duration,so as to ensure the health of nuclear medicine workers.