Correlation analysis between apolipoprotein A-Ⅰ and carotid atherosclerosis in elderly patients with hypertension
Objective To investigate the correlation between apolipoprotein A-Ⅰand carotid atherosclerosis in elderly hyperten-sive patients,and to provide reference for early intervention of risk factors in elderly hypertensive patients.Methods Clinical data of elderly patients with hypertension combined with carotid atherosclerosis in outpatient and inpatient departments of Hohhot First Hos-pital from April 2022 to April 2023 were retrospectively analyzed,and they were selected as the observation group,and the data of outpatient and inpatient hypertension patients during the same period were selected as the control group.All subjects underwent ser-um apolipoprotein A-Ⅰand carotid blood vessel color ultrasonography.The changes of the above indexes were compared,and the cor-relation between apolipoprotein A-Ⅰ and carotid atherosclerosis in elderly patients with hypertension was analyzed.Results The apolipoprotein A-Ⅰ level in the observation group was lower than that in the control group.The maximum flow velocity(Vmax)and minimum flow velocity(Vmin)of internal carotid artery,external carotid artery and common carotid artery were observed by color Doppler ultrasound.There were significant differences in Vmax,Vmin,resistance index RI,tube diameter,intismal thickness,plaque size and carotid artery stenosis(all P<0.05).Conclusion The lower the level of apolipoprotein A-Ⅰwas,the higher the degree of ca-rotid atherosclerosis was,and there was a significant positive correlation between apolipoprotein A-Ⅰ and carotid blood flow and ca-rotid artery stenosis.Apolipoprotein A-Ⅰ level control can be used as an early intervention indicator for elderly patients with hyper-tension combined with carotid atherosclerosis,which helps to delay the occurrence of carotid atherosclerosis in elderly patients with hypertension,thus reducing the incidence of cardiovascular and cerebrovascular diseases and the rate of disability.
hypertensionhypertension in the elderlyapolipoprotein A-Ⅰlow density lipoprotein cholesterolatherosclerosis of the carotid artery
万方数据
维普
