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生物可吸收支架在冠心病介入治疗中的应用

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经皮冠状动脉介入(percutaneous coronary intervention,PCI)手术是冠心病(coronary artery disease,CAD)治疗的优选,目前冠状动脉内植入药物洗脱支架仍是PCI的主要方法,但金属支架永久残留血管内会增加慢性炎症、支架内再狭窄及血栓形成等风险.生物可吸收支架(bioresorbable scaffold,BRS)的问世大大降低了这些风险,由于其可在一定的时间内自行降解,植入部位血管可以恢复结构和收缩舒张功能,正在世界范围内被广泛研究.本文列举了目前应用于临床或正在研发的生物可吸收支架,详细介绍了可吸收支架的原理和结构,包括支架材料、各类型支架的厚度和降解时间等.本文从临床角度分析了可吸收支架在冠心病介入治疗中的优势,如恢复快、并发症少等.本文还对比了可吸收支架与传统金属支架在治疗效果和安全性方面的差异.可吸收支架作为一种新型的冠心病介入治疗器械,可降低晚期不良事件发生率,为患者带来了更为便捷、安全的治疗方案.然而,可吸收支架在实际应用中仍存在一些问题,本文就生物可吸收支架临床应用、最新研究进展等问题等做一综述,以期为生物可吸收支架不断改进并早日进入临床广泛应用阶段提供借鉴.
Application of bioabsorbable stent in the interventional treatment of coronary heart disease
Percutaneous coronary intervention(PCI)is the preferred treatment for coronary artery disease(CAD).Currently,drug-eluting stents(DES)implanted in the coronary artery remain the primary method of PCI.However,the long-term retention of metallic stents in the vessel increases the risk of chronic inflammation,stent thrombosis,and restenosis.The emergence of bioresorbable scaf-folds(BRS)promises to significantly reduce these risks by allowing the vessels to regain their structure and diastolic function after a certain period of degradation.BRS is currently being widely researched worldwide for its potential application in clinical practice.This review summarizes currently available or developing BRS,detailing their principles and structures,including scaffold materials,thick-nesses,and degradation time,etc.Furthermore,this review analyzes from a clinical perspective the advantages of BRS in coronary in-tervention therapy,such as rapid recovery and fewer complications.Finally,this review compares the effectiveness and safety differ-ences between BRS and traditional metallic stents.BRS offers an easier and safer treatment option for patients with CAD,potentially reducing the rate of adverse events in advanced stages.However,there are still some problems in the practical application of BRS.This paper reviews the clinical application and latest research progress of BRS,with a view to providing directions for the con-tinuous improvement of BRS and its early clinical widespread use.

coronary heart diseasepercutaneous coronary artery interventionbioresorbable scaffold

曹干、张晶、方震、邓毅凡、何胜虎

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徐州医科大学扬州临床学院 225001

江苏省苏北人民医院(扬州大学临床医学院)心血管内科 225001

扬州大学医学院 225001

冠心病 经皮冠状动脉介入治疗 生物可吸收支架

2024

中国老年保健医学
中国老年保健医学研究会

中国老年保健医学

影响因子:0.637
ISSN:1672-4860
年,卷(期):2024.22(2)
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