1例罗沙司他药物不良反应病例报告并相关文献复习
A clinical report of Roxadustat related adverse drug reactions and literature review
杨晓丽 1王磊 1范勇霞 1平金超2
作者信息
- 1. 北京市昌平区医院肾病学科 102200
- 2. 北京市昌平区医院血液透析中心 102200
- 折叠
摘要
目的 总结罗沙司他药物使用过程中的常见不良反应,提高临床医生对其不良反应的认知.方法 对1例慢性肾脏病(chronic kidney disease,CKD)血液透析患者口服罗沙司他胶囊后出现的药物相关不良反应进行回顾性分析,并进行文献复习.结果 该患者因肾性贫血口服罗沙司他胶囊后出现严重腹泻、恶心、呕吐症状就诊,完善相关化验检查提示合并肝功能受损,入院后给予连续性床旁血液滤过、保护肝功能、抗感染、补液等治疗,患者症状及化验结果逐渐改善,最终病情好转出院.结论 罗沙司他作为治疗肾性贫血的新型口服药物,其药物安全性仍需要进行进一步的研究,临床医生在使用该药物过程中对其不良反应的认知仍需要进一步加强.
Abstract
Objective To investigate the safety of Roxadustat on anemia to improve understanding of its adverse drug reactions.Methods Clinical data of a patient with dialysis-dependent chronic kidney disease(DD-CKD)and renal anemia who were treated with Roxadustat and experienced treatment-emergent adverse events was retrospectively analyzed,and related literature was reviewed.Results After treated with Roxadustat,the patient has severe symptoms of diarrhea,nausea,and vomiting,and laboratory tests indi-cated concurrent liver failure.After admission,continuous renal replacement therapy(CRRT),protecting liver function,anti-infec-tion,and other treatments were given to the patient.The patient's symptoms and laboratory results gradually improved,and ultimately the patient was discharged from the hospital.Conclusion As a novel oral medication for the renal anemia,further researches are needed on the adverse drug reactions with Roxadustat,we need to strengthen the understanding of its adverse drug reactions during the use of Roxadustat.
关键词
低氧诱导因子脯氨酰羟化酶抑制剂/罗沙司他/不良反应/血液透析/肾性贫血Key words
hypoxia-inducible factor prolyl hydroxylase inhibitor(HIF-PHI)/Roxadustat/renal anemia/adverse drug reactions/renal dialysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据