Meta-analysis of risk factors for refracture in elderly patients with osteoporotic fracture
Objective To analyze the risk factors of refracture in elderly patients with osteoporotic fracture(OPF)and provide evidence-based basis for preventing secondary or multiple fractures.Methods Search the literature published on 15 January 2024 associated with refracture in elderly patients with osteoporotic fracture.Two researchers individually screened,extracted the informa-tion,evaluated the quality,and analyzed the literature.Results 15 articles were included,including 4750 samples and 12 risk fac-tors.Meta-analysis results showed:history of glucocorticoid use(OR=1.97,95％CI 1.40～2.77),bone mineral density(OR=2.54,95％CI 1.87～3.46),preoperative number of fractured vertebral bodies(OR=5.49,95％CI 3.41～8.84),number of opera-ted vertebrae(OR=4.35,95％CI 2.68～7.04),bone cement disc leakage(OR=3.62,95％CI 2.25～5.81),age(OR=3.52,95％CI 2.81～4.41),gender(OR=2.31,95％CI 1.59～3.35),body mass index(OR=7.38,95％CI 2.96～18.40),COPD(OR=2.53,95％CI 1.49～4.28)was a risk factor for refracture in the elderly OPF(P＜0.05).The amount of cement injection,regular exercise,and history of fracture affected elderly OPF(P＞0.05).Conclusion History of glucocorticoid use,bone mineral density,number of preoperative fractures,number of operated vertebrae,leakage of cemented disc,age,sex,body quality index,and COPD are risk factors for refracture in elderly(P＜0.05),and prevention of controllable factors can effectively reduce the risk of refracture.
the agedosteoporotic fracturerefracturerisk factors
万方数据
维普
