Objective To explore the application effect of self-management program based on SDM model in non-dialysis pa-tients with chronic kidney disease.Methods A total of 100 patients hospitalized in the renal department of a Grade-Ⅲ hospital in Yunnan Province from January to June 2022 were selected.They were divided into the control group and the observation group,with 50 cases respectively according to random number table method.The control group was treated with Chronic kidney Disease(CKD)self-management program under conventional health education mode,and the observation group was treated with SDM-based interven-tion program based on the intervention content of the control group.After 3 months of intervention,the self-management ability,health literacy,blood urea nitrogen levels of the two groups were compared.Results The scores of self-management ability in the interven-tion group were higher than those in the control group,and there was a significant difference between the two groups(t=-1.949,P<0.05).The scores of physical function,physical function,physical pain,general health,energy,social function and mental health in the intervention group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The blood urea nitrogen level in the intervention group was lower than that in the control group,and the difference be-tween the two groups was statistically significant(Z=-2.117,P<0.05).Conclusion Self-management intervention program based on SDM can improve the self-management ability of non-dialysis patients with chronic kidney disease,improve the health status of patients,and reduce the blood urea nitrogen level,which has high clinical application value.