五味子乙素抑制胶质瘤生长的作用
The effect of Schisandrin B inhibiting the growth of glioma in vivo
刘晓阳 1王立波 1侯晓节 2刘玉清 2陶玉龙 2金宏 2沈楠 2陈加俊 1齐玲2
作者信息
- 1. 吉林大学中日联谊医院神经内三科,长春 吉林 130033
- 2. 吉林医药学院病理教研室
- 折叠
摘要
目的 探讨五味子乙素对大鼠胶质瘤生长的作用机制.方法 建立Wistar大鼠胶质瘤模型,用200 mg/kg五味子乙素灌胃处理7d,实验结束后取出肿瘤,测定肿瘤的重量和体积,检测大鼠血清中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活力和谷胱甘肽的含量.结果 五味子乙素可明显抑制胶质瘤的生长,用药组肿瘤体积较对照组肿瘤体积明显缩小(P＜0.05)；用药组肿瘤重量较对照组亦明显减少(P＜0.05),药物组大鼠白清谷胱甘肽(GSH),SOD、CAT有所下降,与对照组相比具有统计学意义(P＜0.05).结论 五味子乙素通过影响胶质瘤大鼠血清中氧化应激指标,可以显著地发挥抑制胶质瘤生长的作用.
Abstract
Objective To establish the glioma model of rats,explore the effect of Schisandrin B on the growth of glioma in rats.Methods The glioma model of Wistar rats were established,and then were treated with 200 mg/kg Schisandrin B by intragastric administration for 7 d,the tumors were removed,and the volume and weight of tumors were examined,the levels of superoxide dismutase (SOD),glutathione(GLU) and catalase(CAT) in seum were detected.Results Schisandrin B inhibited the growth of gliomas,the volume of tumors in drug group [(47.10 ± 45.12) mm3] was significantly decreased compared with that of control group [(139.90 ± 74.87) mm3](P ＜ 0.05) ; the weitht of tumors in drug group [(0.12 ± 0.10) g] was significantly decreased than that of control group [(0.15 ± 0.06)g] (P ＜ 0.05) ; the level of SOD,GLU and CAT in serum of rats were decreased than those of control group (P ＜ 0.05).Conclusions Schisandrin B could inhibit the growth of glioma in rats by regulating the level of oxidative stress factors.
关键词
五味子乙素/氧化应激/胶质瘤Key words
Schisandrin B/Oxidative stress/Glioma引用本文复制引用
基金项目
国家自然科学基金(81201671)
吉林省教育厅资助项目(2011281)
吉林省教育厅资助项目(2012330)
出版年
2013
NETL
NSTL
维普
万方数据