Clinical study on the treatment of primary osteoporosis with bone melon extract injection combined with Zoledronic Acid
Objective To explore the therapeutic effect of bone melon extract injection combined with Zoledronic Acid in patients with primary osteoporosis(OP). Methods 90 patients with primary osteoporosis admitted to Shangqiu Traditional Chinese Medicine Hospital from January 2021 to December 2023 were retrospectively selected as the study subjects.According to the treatment plan,they were divided into a reference group(n=45,treated with Zoledronic Acid) and a combination group(n=45,treated with bone melon extract injection combined with Zoledronic Acid).The clinical efficacy,bone mineral density(BMD),N-terminal mid molecular fragment of osteocalcin(N-MID),25 hydroxyvitamin D[25(OH)D],bone alkaline phosphatase(BAP),tartrate resistant acid phosphatase 5b(TRACP-5b),interleukin-1 β(IL-1 β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α) levels,and incidence of adverse reactions between the two groups were compared.Results The clinical efficacy of the combination group was 95.56％,higher than that of the reference group(77.78％),P<0.05;After treatment,the BMD of lumbar vertebrae L1-L4,femoral neck,and hip in the combination group were significantly higher than those in the reference group(P<0.05);Compared with the reference group,the combination group had higher levels of serum N-MID,25(OH)D,and BAP after treatment,and lower levels of TRACP-5b(P<0.05);The decrease range in serum levels of IL-1 β,IL-6,and TNF-α after treatment in the combination group was greater than that in the reference group(P<0.05);There was no difference of statistical significance in the occurrence of adverse reactions between the combination group and the reference group(P>0.05). Conclusion The combination of bone melon extract injection and Zoledronic Acid has significant therapeutic effects on primary osteoporosis patients,which can significantly increase bone density,improve bone metabolism indicators,and reduce serum inflammatory factor levels.
Bone melon extract injectionZoledronic AcidPrimary osteoporosisTherapeutic effect
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