To analyze the crash response,structural energy absorption,and occupant injury of a large aircraft fuselage frame section in the vertical crash test,firstly,the finite element model of typical fuselage frame section-seat-occupant of a large aircraft is established. Secondly,the failure mode of fuselage frame section and occupant response of the test piece and this finite element model are compared and analyzed. Finally,the crash energy absorption is analyzed on different components of the fuselage frame section,and the occupant injury situation is analyzed from the perspec-tives of lumbar compression load and pelvic acceleration. The simulation results show that the finite element model of fuselage frame section-seat-occupant can effectively simulate the failure mode of fuselage frame section,one plastic hinge at the middle support area of the the lower structure of the cargo floor and two plastic hinges at the connections between cabin floor support columns and fuselage frames,and occupant response is effectively vali-dated. From the perspective of energy absorption,at the vertical crash velocity of 6.02 m/s,the fuselage frame,skin and connecting corner pieces are the main energy absorbing components,and from the perspective of occupant in-juries,simulation results show that the lumbar compression load of occupant is less than 6672 N and the pelvic ac-celeration is within the acceptable range of human injury. Furthermore,the dynamic response index (DRI) value obtained from floor acceleration is lower compared with that of pelvic acceleration. The survival space in the cab-in area of the fuselage frame section is maintained,and the injury risk of the occupant lumbar compression load and pelvic acceleration is relatively small for a certain type of aircraft at a crash speed of 6.02 m/s. The research conclu-sion of this article can provide reference for the design of large civil aircraft fuselage structure.